High cholesterol raises your risk for heart attack and stroke, but there are clear options that work. Drugs aren’t a one-size-fits-all fix. Different medicines target different parts of how your body handles cholesterol. This page explains the main choices, common side effects, and simple questions to bring to your next appointment.
Statins (like atorvastatin, simvastatin) are the go-to. They cut LDL (“bad”) cholesterol by blocking the liver enzyme that makes cholesterol. They lower risk of heart events and are usually cheap as generics. Expect the biggest LDL drop for most people.
Ezetimibe (Zetia) lowers cholesterol by reducing absorption from food. It’s often added when statins alone don’t reach targets or when people can’t tolerate high-dose statins.
PCSK9 inhibitors are injectable medicines that can dramatically cut LDL—often used for people with genetic high cholesterol or those who stay high despite other meds. They work great but cost more and may need insurance pre-approval.
Other options include bile acid sequestrants (cholestyramine) that trap cholesterol in the gut, fibrates that help lower triglycerides, and niacin which used to be popular but now sees less use because of side effects and limited benefit in some groups.
Worried about side effects? Muscle pain is the common complaint with statins. It’s usually mild, but severe muscle symptoms need a call to your doctor. Healthy liver tests before and during treatment are standard for some people. Statins should not be used in pregnancy.
Drug interactions matter. Grapefruit can raise levels of certain statins. Blood thinners like warfarin need dose checks if you start or stop a statin. Tell your doctor about every medicine and supplement you take.
Cost and access: Most statins are inexpensive. Newer drugs like PCSK9 inhibitors can be costly but often have manufacturer or insurance programs. Ask your pharmacist about coupons, generics, or patient-assistance programs if price is a concern.
Thinking of buying meds online? Use licensed, verified pharmacies that require a prescription. Avoid sites that sell prescription drugs without a valid script. Read reviews, check for pharmacy licensing, and consult your pharmacist if something looks off.
Questions to ask your clinician: What’s my LDL target? Why this drug over another? What side effects should I watch for? How will we monitor progress? Can lifestyle changes replace or lower the dose of medicine?
Lifestyle still matters. A diet lower in saturated fats, regular exercise, weight loss, and quitting smoking all help and can reduce the amount of drug needed. Take your meds as prescribed — missing doses cuts the benefit.
If you want, bring this list to your appointment. Clear goals and honest talk about side effects and costs make it easier to find the right plan for your heart.